Research Evidence: Full Protocol

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Neural Pathway Therapy: 

A Multimodal Neuromodulation Protocol to Enhance Neuroplasticity and Treat Behavioral Health Disorders

Prepared by:
Neural Science Institute Inc.
Clinical and Scientific Team

Date of Publication:
January 3, 2026

Contact:
Neural Science Institute Inc.
https://neuralscienceinstitute.com/contact
Website: www.neuralscienceinstitute.com

Mental and behavioral health disorders are significant societal and healthcare burdens, with treatment options suffering from limited success and difficulty obtaining objective outcome measurements. A 2022 survey found that 90% of adults believe the United States is in a mental health crisis [1], and the CDC reports that 23% of adults in the United States suffer from a mental health disorder [2]. There are millions of people in need of alternative therapeutic options for mental wellbeing. 

The brain is capable of altering its neuronal circuitry - adding, removing, or tuning the strength of synaptic connections - through a suite of mechanisms collectively termed neuroplasticity. This capacity to change the brain’s structural connectivity, thereby persistently changing the resulting thoughts and behaviors, has significant therapeutic potential for the treatment of mental and behavioral disorders [3]. 

Despite a wealth of research on its induction of neuroplasticity and the considerable clinical efficacy of transcranial magnetic stimulation (TMS), the arduous task of attending many dozens of sessions at specialized treatment centers has hampered its widespread adoption. 

Alternatively, psychedelic and psychedelic-derived pharmaceuticals are beginning to show meaningful clinical benefits for the treatment of numerous mental health disorders, but face increased scrutiny due to Drug Enforcement Agency scheduling and the enormous cost of FDA clinical trial approval, as well as hesitance from the general public due to associations with the hallucinogenic experience. 

Despite the significant resources being invested into promoting neuroplasticity in the human adult, few treatment options are actually available or utilized at scale. 

This paper briefly describes the history of treatments to improve neuroplasticity with an emphasis on neurofeedback modalities. It then highlights the successful, measurable, and evidence based method developed by the Neural Science Institute to promote neuroplasticity and persistent mental wellbeing: Neural Pathway Therapy.